High EVI1 and PARP1 expression as favourable prognostic markers in high-grade serous ovarian carcinoma

• Main Authors: Paul Jank (Author), Jonas Leichsenring (Author), Svenja Kolb (Author), Inga Hoffmann (Author), Philip Bischoff (Author), Catarina Alisa Kunze (Author), Mihnea P. Dragomir (Author), Moritz Gleitsmann (Author), Moritz Jesinghaus (Author), Wolfgang D. Schmitt (Author), Hagen Kulbe (Author), Christine Sers (Author), Albrecht Stenzinger (Author), Jalid Sehouli (Author), Ioana Elena Braicu (Author), Christina Westhoff (Author), David Horst (Author), Carsten Denkert (Author), Stefan Gröschel (Author), Eliane T. Taube (Author)
• Format: Book
• Published: BMC, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Mechanisms of development and progression of high-grade serous ovarian cancer (HGSOC) are poorly understood. EVI1 and PARP1, part of TGF-ß pathway, are upregulated in cancers with DNA repair deficiencies with DNA repair deficiencies and may influce disease progression and surviva...