Deciphering the mechanism of Indirubin and its derivatives in the inhibition of Imatinib resistance using a "drug target prediction-gene microarray analysis-protein network construction" strategy

• Main Authors: Huayao Li (Author), Lijuan Liu (Author), Jing Zhuang (Author), Cun Liu (Author), Chao Zhou (Author), Jing Yang (Author), Chundi Gao (Author), Gongxi Liu (Author), Changgang Sun (Author)
• Format: Bog
• Udgivet: BMC, 2019-03-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Abstract Background The introduction of imatinib revolutionized the treatment of chronic myeloid leukaemia (CML), substantially extending patient survival. However, imatinib resistance is currently a clinical problem for CML. It is very importantto find a strategy to inhibit imatinib resistance. Met...