A Phase 1 first‐in‐human study of the safety, tolerability, and pharmacokinetics of the ROBO2 fusion protein PF‐06730512 in healthy participants

A Phase 1 first‐in‐human study of the safety, tolerability, and pharmacokinetics of the ROBO2 fusion protein PF‐06730512 in healthy participants

Abstract Proteinuria associated with podocyte effacement is a hallmark of focal segmental glomerulosclerosis (FSGS). Preclinical studies implicated ROBO2/SLIT2 signaling in the regulation of podocyte adhesion, and inhibition of this pathway is a novel target to slow FSGS disease progression. This fi...

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Main Authors: Chay Ngee Lim (Author), Constantino Kantaridis (Author), Isabelle Huyghe (Author), Donal Gorman (Author), Stephen Berasi (Author), Gabriele E. Sonnenberg (Author)
Format: Book
Published: Wiley, 2021-08-01T00:00:00Z.
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