A Phase 1 first‐in‐human study of the safety, tolerability, and pharmacokinetics of the ROBO2 fusion protein PF‐06730512 in healthy participants

• Prif Awduron: Chay Ngee Lim (Awdur), Constantino Kantaridis (Awdur), Isabelle Huyghe (Awdur), Donal Gorman (Awdur), Stephen Berasi (Awdur), Gabriele E. Sonnenberg (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: Wiley, 2021-08-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

Abstract Proteinuria associated with podocyte effacement is a hallmark of focal segmental glomerulosclerosis (FSGS). Preclinical studies implicated ROBO2/SLIT2 signaling in the regulation of podocyte adhesion, and inhibition of this pathway is a novel target to slow FSGS disease progression. This fi...