The influence of OATP2B1 and atorvastatin on coproporphyrin isomers in rats

• Main Authors: Jonny Kinzi (Author), Markus Grube (Author), Janine Hussner (Author), Isabell Seibert (Author), Matthias Hamburger (Author), Henriette E. Meyer zu Schwabedissen (Author)
• Format: Book
• Published: Elsevier, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Coproporphyrin I (CPI) and III (CPIII) are discussed as biomarkers for organic anion transporting polypeptides (OATPs). We report on CPI and CPIII levels in wildtype, rSlco2b1-knockout, and SLCO2B1-humanized rats at baseline and after administration of atorvastatin, an inhibitor of the CPIII-specifi...