Effects of triclabendazole and its metabolite exposure on the heart‐rate-corrected QT intervals: A randomized, placebo‐ and positive‐controlled thorough QT study in healthy individuals

• Auteurs principaux: William T. Prince (Auteur), Vinay Kumar Venishetty (Auteur), Jean Lecot (Auteur), Kasra Shakeri‐Nejad (Auteur), Cathy Gray (Auteur), Amanda Taylor (Auteur), Ganesh R. Iyer (Auteur), Julia Zack (Auteur)
• Format: Livre
• Publié: Wiley, 2023-10-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Abstract Triclabendazole is an effective and well‐tolerated treatment for human fascioliasis. A placebo‐ and positive‐controlled, four‐sequence by four‐period crossover study was conducted in 45 healthy participants to assess the effect of therapeutic (10 mg/kg twice daily [b.i.d.] for 1 day) and su...