Effects of triclabendazole and its metabolite exposure on the heart‐rate-corrected QT intervals: A randomized, placebo‐ and positive‐controlled thorough QT study in healthy individuals

• Autors principals: William T. Prince (Autor), Vinay Kumar Venishetty (Autor), Jean Lecot (Autor), Kasra Shakeri‐Nejad (Autor), Cathy Gray (Autor), Amanda Taylor (Autor), Ganesh R. Iyer (Autor), Julia Zack (Autor)
• Format: Llibre
• Publicat: Wiley, 2023-10-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

Abstract Triclabendazole is an effective and well‐tolerated treatment for human fascioliasis. A placebo‐ and positive‐controlled, four‐sequence by four‐period crossover study was conducted in 45 healthy participants to assess the effect of therapeutic (10 mg/kg twice daily [b.i.d.] for 1 day) and su...