Effects of triclabendazole and its metabolite exposure on the heart‐rate-corrected QT intervals: A randomized, placebo‐ and positive‐controlled thorough QT study in healthy individuals

• Päätekijät: William T. Prince (Tekijä), Vinay Kumar Venishetty (Tekijä), Jean Lecot (Tekijä), Kasra Shakeri‐Nejad (Tekijä), Cathy Gray (Tekijä), Amanda Taylor (Tekijä), Ganesh R. Iyer (Tekijä), Julia Zack (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Wiley, 2023-10-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Abstract Triclabendazole is an effective and well‐tolerated treatment for human fascioliasis. A placebo‐ and positive‐controlled, four‐sequence by four‐period crossover study was conducted in 45 healthy participants to assess the effect of therapeutic (10 mg/kg twice daily [b.i.d.] for 1 day) and su...