Engineering death resistance in CHO cells for improved perfusion culture

• मुख्य लेखकों: Michael A. MacDonald (लेखक), Matthias Nöbel (लेखक), Verónica S. Martínez (लेखक), Kym Baker (लेखक), Evan Shave (लेखक), Peter P. Gray (लेखक), Stephen Mahler (लेखक), Trent Munro (लेखक), Lars K. Nielsen (लेखक), Esteban Marcellin (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The reliable and cost-efficient manufacturing of monoclonal antibodies (mAbs) is essential to fulfil their ever-growing demand. Cell death in bioreactors reduces productivity and product quality, and is largely attributed to apoptosis. In perfusion bioreactors, this leads to the necessity of a bleed...