Engineering death resistance in CHO cells for improved perfusion culture

• Main Authors: Michael A. MacDonald (Author), Matthias Nöbel (Author), Verónica S. Martínez (Author), Kym Baker (Author), Evan Shave (Author), Peter P. Gray (Author), Stephen Mahler (Author), Trent Munro (Author), Lars K. Nielsen (Author), Esteban Marcellin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The reliable and cost-efficient manufacturing of monoclonal antibodies (mAbs) is essential to fulfil their ever-growing demand. Cell death in bioreactors reduces productivity and product quality, and is largely attributed to apoptosis. In perfusion bioreactors, this leads to the necessity of a bleed...