Engineering death resistance in CHO cells for improved perfusion culture

• Главные авторы: Michael A. MacDonald (Автор), Matthias Nöbel (Автор), Verónica S. Martínez (Автор), Kym Baker (Автор), Evan Shave (Автор), Peter P. Gray (Автор), Stephen Mahler (Автор), Trent Munro (Автор), Lars K. Nielsen (Автор), Esteban Marcellin (Автор)
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• Опубликовано: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Предметы: article
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The reliable and cost-efficient manufacturing of monoclonal antibodies (mAbs) is essential to fulfil their ever-growing demand. Cell death in bioreactors reduces productivity and product quality, and is largely attributed to apoptosis. In perfusion bioreactors, this leads to the necessity of a bleed...