Genetic Variations and Cisplatin Nephrotoxicity: A Systematic Review

• Main Authors: Zulfan Zazuli (Author), Susanne Vijverberg (Author), Elise Slob (Author), Geoffrey Liu (Author), Bruce Carleton (Author), Joris Veltman (Author), Paul Baas (Author), Rosalinde Masereeuw (Author), Anke-Hilse Ma (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Nephrotoxicity is a notable adverse effect in cisplatin treated patients characterized by tubular injury and/or increased serum creatinine (SCr) with incidence varying from 20 to 70%. Pharmacogenomics has been shown to identify strongly predictive genetic markers to help determine which...