The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136

• Main Authors: Fabiola Garcia Cortizo (Author), Daniel Pfaff (Author), Angela Wirth (Author), Andrea Schlotterer (Author), Rebekka Medert (Author), Jakob Morgenstern (Author), Tobias Weber (Author), Hans-Peter Hammes (Author), Thomas Fleming (Author), Peter Paul Nawroth (Author), Marc Freichel (Author), Aurelio A. Teleman (Author)
• Format: Book
• Published: Elsevier, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Methylglyoxal (MG) is a highly reactive α-oxoaldehyde that glycates proteins. MG has been linked to the development of diabetic complications: MG is the major precursor of advanced glycation end products (AGEs), a risk marker for diabetic complications in humans. Furthermore, flies and fi...