The activity of glyoxylase 1 is regulated by glucose-responsive phosphorylation on Tyr136

• Autores principales: Fabiola Garcia Cortizo (Autor), Daniel Pfaff (Autor), Angela Wirth (Autor), Andrea Schlotterer (Autor), Rebekka Medert (Autor), Jakob Morgenstern (Autor), Tobias Weber (Autor), Hans-Peter Hammes (Autor), Thomas Fleming (Autor), Peter Paul Nawroth (Autor), Marc Freichel (Autor), Aurelio A. Teleman (Autor)
• Formato: Libro
• Publicado: Elsevier, 2022-01-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Objective: Methylglyoxal (MG) is a highly reactive α-oxoaldehyde that glycates proteins. MG has been linked to the development of diabetic complications: MG is the major precursor of advanced glycation end products (AGEs), a risk marker for diabetic complications in humans. Furthermore, flies and fi...