UTP - Gated Signaling Pathways of 5-HT Release from BON Cells as a Model of Human Enterochromaffin Cells

• Main Authors: Andromeda Liñán-Rico (Author), Fernando Ochoa-Cortes (Author), Alix Zuleta-Alarcon (Author), Mazin Alhaj (Author), Esmerina Tili (Author), Josh Enneking (Author), Alan Harzman (Author), Iveta Grants (Author), Sergio Bergese (Author), Fievos L. Christofi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2017-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Enterochromaffin cells (EC) synthesize and release 5-HT and ATP to trigger or modulate gut neural reflexes and transmit information about visceral/pain sensation. Alterations in 5-HT signaling mechanisms may contribute to the pathogenesis of IBD or IBS, but the pharmacologic or molecular...