Development of a Positive-readout Mouse Model of siRNA Pharmacodynamics

• Main Authors: Mark Stevenson (Author), Robert Carlisle (Author), Ben Davies (Author), Chris Preece (Author), Michelle Hammett (Author), Wei-li Liu (Author), Kerry David Fisher (Author), Amy Ryan (Author), Heidi Scrable (Author), Leonard William Seymour (Author)
• Format: Book
• Published: Elsevier, 2013-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Development of RNAi-based therapeutics has the potential to revolutionize treatment options for a range of human diseases. However, as with gene therapy, a major barrier to progress is the lack of methods to achieve and measure efficient delivery for systemic administration. We have developed a posi...