Development of a Positive-readout Mouse Model of siRNA Pharmacodynamics

• Egile Nagusiak: Mark Stevenson (Egilea), Robert Carlisle (Egilea), Ben Davies (Egilea), Chris Preece (Egilea), Michelle Hammett (Egilea), Wei-li Liu (Egilea), Kerry David Fisher (Egilea), Amy Ryan (Egilea), Heidi Scrable (Egilea), Leonard William Seymour (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2013-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Development of RNAi-based therapeutics has the potential to revolutionize treatment options for a range of human diseases. However, as with gene therapy, a major barrier to progress is the lack of methods to achieve and measure efficient delivery for systemic administration. We have developed a posi...