The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles

• Principais autores: Emilia Szymańska (Autor), Katarzyna Woś-Latosi (Autor), Julia Jacyna (Autor), Magdalena Dąbrowska (Autor), Joanna Potaś (Autor), Michał Jan Markuszewski (Autor), Katarzyna Winnicka (Autor)
• Formato: Livro
• Publicado em: MDPI AG, 2020-05-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Microparticles containing water-soluble zidovudine were prepared by spray-drying using chitosan glutamate and beta-glycerophosphate as an ion crosslinker (CF). The Box-Behnken design was applied to optimize the microparticles in terms of their drug loading and release behavior. Physicochemical studi...