The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles

• Váldodahkkit: Emilia Szymańska (Dahkki), Katarzyna Woś-Latosi (Dahkki), Julia Jacyna (Dahkki), Magdalena Dąbrowska (Dahkki), Joanna Potaś (Dahkki), Michał Jan Markuszewski (Dahkki), Katarzyna Winnicka (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2020-05-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Microparticles containing water-soluble zidovudine were prepared by spray-drying using chitosan glutamate and beta-glycerophosphate as an ion crosslinker (CF). The Box-Behnken design was applied to optimize the microparticles in terms of their drug loading and release behavior. Physicochemical studi...