The Correlation between Physical Crosslinking and Water-Soluble Drug Release from Chitosan-Based Microparticles
Microparticles containing water-soluble zidovudine were prepared by spray-drying using chitosan glutamate and beta-glycerophosphate as an ion crosslinker (CF). The Box-Behnken design was applied to optimize the microparticles in terms of their drug loading and release behavior. Physicochemical studi...
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