Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion.

• Hoofdauteurs: Shridhar Bale (Auteur), Tong Liu (Auteur), Sheng Li (Auteur), Yuhao Wang (Auteur), Dafna Abelson (Auteur), Marnie Fusco (Auteur), Virgil L Woods (Auteur), Erica Ollmann Saphire (Auteur)
• Formaat: Boek
• Gepubliceerd in: Public Library of Science (PLoS), 2011-11-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Ebolavirus belongs to the family filoviridae and causes severe hemorrhagic fever in humans with 50-90% lethality. Detailed understanding of how the viruses attach to and enter new host cells is critical to development of medical interventions. The virus displays a trimeric glycoprotein (GP(1,2)) on...