Ebola virus glycoprotein needs an additional trigger, beyond proteolytic priming for membrane fusion.

• Main Authors: Shridhar Bale (Author), Tong Liu (Author), Sheng Li (Author), Yuhao Wang (Author), Dafna Abelson (Author), Marnie Fusco (Author), Virgil L Woods (Author), Erica Ollmann Saphire (Author)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2011-11-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Ebolavirus belongs to the family filoviridae and causes severe hemorrhagic fever in humans with 50-90% lethality. Detailed understanding of how the viruses attach to and enter new host cells is critical to development of medical interventions. The virus displays a trimeric glycoprotein (GP(1,2)) on...