Down-Regulation of the Na+-Coupled Phosphate Transporter NaPi-IIa by AMP-Activated Protein Kinase

• Main Authors: Miribane Dërmaku-Sopjani (Author), Ahmad Almilaji (Author), Tatsiana Pakladok (Author), Carlos Munoz (Author), Zohreh Hosseinzadeh (Author), María Blecua (Author), Mentor Sopjani (Author), Florian Lang (Author)
• Format: Book
• Published: Karger Publishers, 2013-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background/Aims: The Na+-coupled phosphate transporter NaPi-IIa is the main carrier accomplishing renal tubular phosphate reabsorption. It is driven by the electrochemical Na+ gradient across the apical cell membrane, which is maintained by Na+ extrusion across the basolateral cell membrane through...