Physiologically based radiopharmacokinetic (PBRPK) modeling to simulate and analyze radiopharmaceutical therapies: studies of non-linearities, multi-bolus injections, and albumin binding

• Autori principali: Ali Fele-Paranj (Autore), Babak Saboury (Autore), Carlos Uribe (Autore), Arman Rahmim (Autore)
• Natura: Libro
• Pubblicazione: SpringerOpen, 2024-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Background We aimed to develop a publicly shared computational physiologically based pharmacokinetic (PBPK) model to reliably simulate and analyze radiopharmaceutical therapies (RPTs), including probing of hot-cold ligand competitions as well as alternative injection scenarios and drug desi...