Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3

• Päätekijät: Junfeng Li (Tekijä), Yan Huang (Tekijä), Xinyu Yang (Tekijä), Yuli Cai (Tekijä), Ye Wang (Tekijä), Wenling Dai (Tekijä), Liu Jiang (Tekijä), Changhua Wang (Tekijä), Zhongyuan Wen (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Elsevier, 2024-05-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Objective: Hepatic insulin resistance, which leads to increased hepatic gluconeogenesis, is a major contributor to fasting hyperglycemia in type 2 diabetes mellitus (T2DM). However, the mechanism of impaired insulin-dependent suppression of hepatic gluconeogenesis remains elusive. Delta/Notch-like e...