Tyrosine-phosphorylated DNER sensitizes insulin signaling in hepatic gluconeogenesis by inducing proteasomal degradation of TRB3

• Main Authors: Junfeng Li (Author), Yan Huang (Author), Xinyu Yang (Author), Yuli Cai (Author), Ye Wang (Author), Wenling Dai (Author), Liu Jiang (Author), Changhua Wang (Author), Zhongyuan Wen (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Hepatic insulin resistance, which leads to increased hepatic gluconeogenesis, is a major contributor to fasting hyperglycemia in type 2 diabetes mellitus (T2DM). However, the mechanism of impaired insulin-dependent suppression of hepatic gluconeogenesis remains elusive. Delta/Notch-like e...