Direct comparison of the next-generation sequencing and iTERT PCR methods for the diagnosis of TERT hotspot mutations in advanced solid cancers

• Главные авторы: So Young Kang (Автор), Deok Geun Kim (Автор), Hyunjin Kim (Автор), Yoon Ah Cho (Автор), Sang Yun Ha (Автор), Ghee Young Kwon (Автор), Kee-Taek Jang (Автор), Kyoung-Mee Kim (Автор)
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• Опубликовано: BMC, 2022-02-01T00:00:00Z.
• Предметы: article
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Abstract Background Mutations in the telomerase reverse transcriptase (TERT) promoter region have been proposed as novel mechanisms for the transcriptional activation of telomerase. Two recurrent mutations in the TERT promoter, C228T and C250T, are prognostic biomarkers. Herein, we directly compared...