Direct comparison of the next-generation sequencing and iTERT PCR methods for the diagnosis of TERT hotspot mutations in advanced solid cancers

• Main Authors: So Young Kang (Author), Deok Geun Kim (Author), Hyunjin Kim (Author), Yoon Ah Cho (Author), Sang Yun Ha (Author), Ghee Young Kwon (Author), Kee-Taek Jang (Author), Kyoung-Mee Kim (Author)
• Format: Book
• Published: BMC, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Mutations in the telomerase reverse transcriptase (TERT) promoter region have been proposed as novel mechanisms for the transcriptional activation of telomerase. Two recurrent mutations in the TERT promoter, C228T and C250T, are prognostic biomarkers. Herein, we directly compared...