Induction Apoptosis of Erinacine A in Human Colorectal Cancer Cells Involving the Expression of TNFR, Fas, and Fas Ligand via the JNK/p300/p50 Signaling Pathway With Histone Acetylation

• Main Authors: Ko-Chao Lee (Author), Kam-Fai Lee (Author), Shui-Yi Tung (Author), Wen-Shih Huang (Author), Li-Ya Lee (Author), Wan-Ping Chen (Author), Chin-Chu Chen (Author), Chih-Chuan Teng (Author), Chien-Heng Shen (Author), Meng-Chiao Hsieh (Author), Hsing-Chun Kuo (Author)
• Format: Book
• Published: Frontiers Media S.A., 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Erinacine A, which is one of the major bioactive diterpenoid compounds extracted from cultured mycelia of H. erinaceus, displays great antitumorigenic activity. However, the molecular mechanisms underlying erinacine A inducing cancer cell apoptosis in colorectal cancer (CRC) remain unclear. This stu...