Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.

• Main Authors: Roy Mwenechanya (Author), Julie Kovářová (Author), Nicholas J Dickens (Author), Manikhandan Mudaliar (Author), Pawel Herzyk (Author), Isabel M Vincent (Author), Stefan K Weidt (Author), Karl E Burgess (Author), Richard J S Burchmore (Author), Andrew W Pountain (Author), Terry K Smith (Author), Darren J Creek (Author), Dong-Hyun Kim (Author), Galina I Lepesheva (Author), Michael P Barrett (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understanding the risks and mechanisms of resistance is there...