Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.

• Asıl Yazarlar: Roy Mwenechanya (Yazar), Julie Kovářová (Yazar), Nicholas J Dickens (Yazar), Manikhandan Mudaliar (Yazar), Pawel Herzyk (Yazar), Isabel M Vincent (Yazar), Stefan K Weidt (Yazar), Karl E Burgess (Yazar), Richard J S Burchmore (Yazar), Andrew W Pountain (Yazar), Terry K Smith (Yazar), Darren J Creek (Yazar), Dong-Hyun Kim (Yazar), Galina I Lepesheva (Yazar), Michael P Barrett (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Public Library of Science (PLoS), 2017-06-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understanding the risks and mechanisms of resistance is there...