Sterol 14α-demethylase mutation leads to amphotericin B resistance in Leishmania mexicana.

• Glavni autori: Roy Mwenechanya (Autor), Julie Kovářová (Autor), Nicholas J Dickens (Autor), Manikhandan Mudaliar (Autor), Pawel Herzyk (Autor), Isabel M Vincent (Autor), Stefan K Weidt (Autor), Karl E Burgess (Autor), Richard J S Burchmore (Autor), Andrew W Pountain (Autor), Terry K Smith (Autor), Darren J Creek (Autor), Dong-Hyun Kim (Autor), Galina I Lepesheva (Autor), Michael P Barrett (Autor)
• Format: Knjiga
• Izdano: Public Library of Science (PLoS), 2017-06-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Amphotericin B has emerged as the therapy of choice for use against the leishmaniases. Administration of the drug in its liposomal formulation as a single injection is being promoted in a campaign to bring the leishmaniases under control. Understanding the risks and mechanisms of resistance is there...