Naldemedine-induced perforation of a diverticulum in the sigmoid colon of a patient with opioid-related constipation: a case report

• Main Authors: Hayato Yokota (Author), Yumiko Akamine (Author), Mizuki Kobayashi (Author), Takuro Kitabayashi (Author), Misato Horie (Author), Tentaro Endo (Author), Takechiyo Yamada (Author), Masafumi Kikuchi (Author)
• Format: Book
• Published: BMC, 2024-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Naldemedine is an orally available peripherally acting μ-opioid receptor antagonist approved to treat opioid-induced constipation (OIC). It is contraindicated for patients with known or suspected gastrointestinal obstruction to protect against naldemedine-induced perforation. Her...