IL-38 blockade induces anti-tumor immunity by abrogating tumor-mediated suppression of early immune activation

• Main Authors: John P. Dowling (Author), Pavel A. Nikitin (Author), Fang Shen (Author), Halley Shukla (Author), James P. Finn (Author), Nirja Patel (Author), Cezary Swider (Author), Jamie L. Bingaman-Steele (Author), Chris Nicolescu (Author), Eden L Sikorski (Author), Evan J. Greenawalt (Author), Michael J. Morin (Author), Matthew K. Robinson (Author), Karen Lundgren (Author), Benjamin C. Harman (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTImmune checkpoint inhibitors that overcome T cell suppressive mechanisms in tumors have revolutionized the treatment of cancer but are only efficacious in a small subset of patients. Targeting suppressive mechanisms acting on innate immune cells could significantly improve the incidence of c...