IL-38 blockade induces anti-tumor immunity by abrogating tumor-mediated suppression of early immune activation

• المؤلفون الرئيسيون: John P. Dowling (مؤلف), Pavel A. Nikitin (مؤلف), Fang Shen (مؤلف), Halley Shukla (مؤلف), James P. Finn (مؤلف), Nirja Patel (مؤلف), Cezary Swider (مؤلف), Jamie L. Bingaman-Steele (مؤلف), Chris Nicolescu (مؤلف), Eden L Sikorski (مؤلف), Evan J. Greenawalt (مؤلف), Michael J. Morin (مؤلف), Matthew K. Robinson (مؤلف), Karen Lundgren (مؤلف), Benjamin C. Harman (مؤلف)
• التنسيق: كتاب
• منشور في: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

ABSTRACTImmune checkpoint inhibitors that overcome T cell suppressive mechanisms in tumors have revolutionized the treatment of cancer but are only efficacious in a small subset of patients. Targeting suppressive mechanisms acting on innate immune cells could significantly improve the incidence of c...