Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases

• Main Authors: Vijay Pralhad Kale (Author), Jeremy A. Hengst (Author), Arati K. Sharma (Author), Upendarrao Golla (Author), Sinisa Dovat (Author), Shantu G. Amin (Author), Jong K. Yun (Author), Dhimant H. Desai (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2023-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The Rho associated coiled-coil containing protein kinase (ROCK1 and ROCK2) and myotonic dystrophy-related Cdc-42 binding kinases (MRCKα and MRCKβ) are critical regulators of cell proliferation and cell plasticity, a process intimately involved in cancer cell migration and invasion. Previously, we re...