Characterization of Anticancer Effects of the Analogs of DJ4, a Novel Selective Inhibitor of ROCK and MRCK Kinases

• Auteurs principaux: Vijay Pralhad Kale (Auteur), Jeremy A. Hengst (Auteur), Arati K. Sharma (Auteur), Upendarrao Golla (Auteur), Sinisa Dovat (Auteur), Shantu G. Amin (Auteur), Jong K. Yun (Auteur), Dhimant H. Desai (Auteur)
• Format: Livre
• Publié: MDPI AG, 2023-07-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

The Rho associated coiled-coil containing protein kinase (ROCK1 and ROCK2) and myotonic dystrophy-related Cdc-42 binding kinases (MRCKα and MRCKβ) are critical regulators of cell proliferation and cell plasticity, a process intimately involved in cancer cell migration and invasion. Previously, we re...