Differently increased volumes of multiple brain areas in Npc1 mutant mice following various drug treatments

• Principais autores: Veronica Antipova (Autor), Diana Heimes (Autor), Katharina Seidel (Autor), Jennifer Schulz (Autor), Oliver Schmitt (Autor), Carsten Holzmann (Autor), Arndt Rolfs (Autor), Hans-Jürgen Bidmon (Autor), Estibaliz González de San Román Martín (Autor), Pitter F. Huesgen (Autor), Katrin Amunts (Autor), Jonas Keiler (Autor), Niels Hammer (Autor), Martin Witt (Autor), Andreas Wree (Autor)
• Formato: Livro
• Publicado em: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

BackgroundNiemann-Pick disease type C1 (NPC1, MIM 257220) is a heritable lysosomal storage disease characterized by a progressive neurological degeneration that causes disability and premature death. A murine model of Npc1−/− displays a rapidly progressing form of Npc1 disease, which is characterize...