Differently increased volumes of multiple brain areas in Npc1 mutant mice following various drug treatments

• Main Authors: Veronica Antipova (Author), Diana Heimes (Author), Katharina Seidel (Author), Jennifer Schulz (Author), Oliver Schmitt (Author), Carsten Holzmann (Author), Arndt Rolfs (Author), Hans-Jürgen Bidmon (Author), Estibaliz González de San Román Martín (Author), Pitter F. Huesgen (Author), Katrin Amunts (Author), Jonas Keiler (Author), Niels Hammer (Author), Martin Witt (Author), Andreas Wree (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundNiemann-Pick disease type C1 (NPC1, MIM 257220) is a heritable lysosomal storage disease characterized by a progressive neurological degeneration that causes disability and premature death. A murine model of Npc1−/− displays a rapidly progressing form of Npc1 disease, which is characterize...