The Impact of Melatonin Supplementation and NLRP3 Inflammasome Deletion on Age-Accompanied Cardiac Damage

• Main Authors: Ramy K. A. Sayed (Author), Marisol Fernández-Ortiz (Author), Ibtissem Rahim (Author), José Fernández-Martínez (Author), Paula Aranda-Martínez (Author), Iryna Rusanova (Author), Laura Martínez-Ruiz (Author), Reem M. Alsaadawy (Author), Germaine Escames (Author), Darío Acuña-Castroviejo (Author)
• Format: Book
• Published: MDPI AG, 2021-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

To investigate the role of NLRP3 inflammasome in cardiac aging, we evaluate here morphological and ultrastructural age-related changes of cardiac muscles fibers in wild-type and NLRP3-knockout mice, as well as studying the beneficial effect of melatonin therapy. The results clarified the beginning o...