Quality by Design (QbD) Approach to Develop Colon-Specific Ketoprofen Hot-Melt Extruded Pellets: Impact of Eudragit^® S 100 Coating on the In Vitro Drug Release

• Үндсэн зохиолчид: Sateesh Kumar Vemula (Зохиогч), Sagar Narala (Зохиогч), Prateek Uttreja (Зохиогч), Nagarjuna Narala (Зохиогч), Bhaskar Daravath (Зохиогч), Chamundeswara Srinivasa Akash Kalla (Зохиогч), Srikanth Baisa (Зохиогч), Siva Ram Munnangi (Зохиогч), Naveen Chella (Зохиогч), Michael A. Repka (Зохиогч)
• Формат: Ном
• Хэвлэсэн: MDPI AG, 2024-09-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Background: A pelletizer paired with hot-melt extrusion technology (HME) was used to develop colon-targeted pellets for ketoprofen (KTP). Thermal stability and side effects in the upper gastrointestinal tract made ketoprofen more suitable for this work. Methods: The pellets were prepared using the e...