Quality by Design (QbD) Approach to Develop Colon-Specific Ketoprofen Hot-Melt Extruded Pellets: Impact of Eudragit^® S 100 Coating on the In Vitro Drug Release

• Main Authors: Sateesh Kumar Vemula (Author), Sagar Narala (Author), Prateek Uttreja (Author), Nagarjuna Narala (Author), Bhaskar Daravath (Author), Chamundeswara Srinivasa Akash Kalla (Author), Srikanth Baisa (Author), Siva Ram Munnangi (Author), Naveen Chella (Author), Michael A. Repka (Author)
• Format: Book
• Published: MDPI AG, 2024-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: A pelletizer paired with hot-melt extrusion technology (HME) was used to develop colon-targeted pellets for ketoprofen (KTP). Thermal stability and side effects in the upper gastrointestinal tract made ketoprofen more suitable for this work. Methods: The pellets were prepared using the e...