Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice

• Autori principali: Ruifeng Mao (Autore), Menglan Yang (Autore), Rui Yang (Autore), Yingying Chen (Autore), Enjie Diao (Autore), Tong Zhang (Autore), Dengchao Li (Autore), Xin Chang (Autore), Zhenjing Chi (Autore), Yefu Wang (Autore)
• Natura: Libro
• Pubblicazione: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Antigen-specific immune tolerance, which possesses great potential in preventing or curing type 1 diabetes mellitus (T1DM), can be induced by oral vaccination with T1DM-related autoantigens. However, direct administration of autoantigens via oral route exhibits a low tolerance-inducing effect as a r...