Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice

• Main Authors: Ruifeng Mao (Author), Menglan Yang (Author), Rui Yang (Author), Yingying Chen (Author), Enjie Diao (Author), Tong Zhang (Author), Dengchao Li (Author), Xin Chang (Author), Zhenjing Chi (Author), Yefu Wang (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Antigen-specific immune tolerance, which possesses great potential in preventing or curing type 1 diabetes mellitus (T1DM), can be induced by oral vaccination with T1DM-related autoantigens. However, direct administration of autoantigens via oral route exhibits a low tolerance-inducing effect as a r...