Oral delivery of the intracellular domain of the insulinoma-associated protein 2 (IA-2ic) by bacterium-like particles (BLPs) prevents type 1 diabetes mellitus in NOD mice

• Auteurs principaux: Ruifeng Mao (Auteur), Menglan Yang (Auteur), Rui Yang (Auteur), Yingying Chen (Auteur), Enjie Diao (Auteur), Tong Zhang (Auteur), Dengchao Li (Auteur), Xin Chang (Auteur), Zhenjing Chi (Auteur), Yefu Wang (Auteur)
• Format: Livre
• Publié: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Antigen-specific immune tolerance, which possesses great potential in preventing or curing type 1 diabetes mellitus (T1DM), can be induced by oral vaccination with T1DM-related autoantigens. However, direct administration of autoantigens via oral route exhibits a low tolerance-inducing effect as a r...