Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice

• मुख्य लेखकों: Mallory Little (लेखक), Moumita Dutta (लेखक), Hao Li (लेखक), Adam Matson (लेखक), Xiaojian Shi (लेखक), Gabby Mascarinas (लेखक), Bruk Molla (लेखक), Kris Weigel (लेखक), Haiwei Gu (लेखक), Sridhar Mani (लेखक), Julia Yue Cui (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-02-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) is well-known to increase drug metabolism and reduce inflammation. Little is known regarding their physiological functions on the gut microbiome. In this study,...