Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice

• প্রধান লেখক: Mallory Little (লেখক), Moumita Dutta (লেখক), Hao Li (লেখক), Adam Matson (লেখক), Xiaojian Shi (লেখক), Gabby Mascarinas (লেখক), Bruk Molla (লেখক), Kris Weigel (লেখক), Haiwei Gu (লেখক), Sridhar Mani (লেখক), Julia Yue Cui (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2022-02-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) is well-known to increase drug metabolism and reduce inflammation. Little is known regarding their physiological functions on the gut microbiome. In this study,...