Understanding the physiological functions of the host xenobiotic-sensing nuclear receptors PXR and CAR on the gut microbiome using genetically modified mice

• Main Authors: Mallory Little (Author), Moumita Dutta (Author), Hao Li (Author), Adam Matson (Author), Xiaojian Shi (Author), Gabby Mascarinas (Author), Bruk Molla (Author), Kris Weigel (Author), Haiwei Gu (Author), Sridhar Mani (Author), Julia Yue Cui (Author)
• Format: Book
• Published: Elsevier, 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pharmacological activation of the xenobiotic-sensing nuclear receptors pregnane X receptor (PXR) and constitutive androstane receptor (CAR) is well-known to increase drug metabolism and reduce inflammation. Little is known regarding their physiological functions on the gut microbiome. In this study,...