Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain

Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain

Delivering glial cell line-derived neurotrophic factor (GDNF) to the brain is a potential treatment for Parkinson's Disease (PD). Here we use an implantable encapsulated cell technology that uses modified human clonal ARPE-19 ​cells to deliver of GDNF to the brain. In vivo studies demonstrated...

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Main Authors: Lars U. Wahlberg (Author), Dwaine F. Emerich (Author), Jeffrey H. Kordower (Author), William Bell (Author), Tracie Fradet (Author), Giovanna Paolone (Author)
Format: Book
Published: Elsevier, 2020-04-01T00:00:00Z.
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3rd Floor Main Library

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