Long-term, stable, targeted biodelivery and efficacy of GDNF from encapsulated cells in the rat and Goettingen miniature pig brain

• Главные авторы: Lars U. Wahlberg (Автор), Dwaine F. Emerich (Автор), Jeffrey H. Kordower (Автор), William Bell (Автор), Tracie Fradet (Автор), Giovanna Paolone (Автор)
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• Опубликовано: Elsevier, 2020-04-01T00:00:00Z.
• Предметы: article
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Delivering glial cell line-derived neurotrophic factor (GDNF) to the brain is a potential treatment for Parkinson's Disease (PD). Here we use an implantable encapsulated cell technology that uses modified human clonal ARPE-19 ​cells to deliver of GDNF to the brain. In vivo studies demonstrated...