The Effect of Length and Structure of Attached Polyethylene Glycol Chain on Hydrodynamic Radius, and Separation of PEGylated Human Serum Albumin by Chromatography

• Päätekijät: Parvin Akbarzadehlaleh (Tekijä), Mona Mirzaei (Tekijä), Mahdiyeh Mashahdi-keshtiban (Tekijä), Hamid Reza Heidari (Tekijä)
• Aineistotyyppi: Kirja
• Julkaistu: Tabriz University of Medical Sciences, 2021-09-01T00:00:00Z.
• Aiheet: article
• Linkit: Connect to this object online.

Purpose: This study focuses on the effect of length and structure of attached polyethylene glycol (PEG) chain on hydrodynamic radius (Rh ) and chromatographic retention of PEGylated protein. To this aim human serum albumin (HSA) as a standard protein was PEGylated site specifically with mPEG-maleimi...