Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products

• Main Authors: Ana Luiza Lima (Author), Ludmila A. G. Pinho (Author), Juliano A. Chaker (Author), Livia L. Sa-Barreto (Author), Ricardo Neves Marreto (Author), Tais Gratieri (Author), Guilherme M. Gelfuso (Author), Marcilio Cunha-Filho (Author)
• Format: Book
• Published: MDPI AG, 2020-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug. Extrudates were obtained under reduced torque (up to 0.3 Nm) at 100 °C to preserve the stability...