Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products

• Asıl Yazarlar: Ana Luiza Lima (Yazar), Ludmila A. G. Pinho (Yazar), Juliano A. Chaker (Yazar), Livia L. Sa-Barreto (Yazar), Ricardo Neves Marreto (Yazar), Tais Gratieri (Yazar), Guilherme M. Gelfuso (Yazar), Marcilio Cunha-Filho (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2020-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug. Extrudates were obtained under reduced torque (up to 0.3 Nm) at 100 °C to preserve the stability...