Hot-Melt Extrusion as an Advantageous Technology to Obtain Effervescent Drug Products

• Auteurs principaux: Ana Luiza Lima (Auteur), Ludmila A. G. Pinho (Auteur), Juliano A. Chaker (Auteur), Livia L. Sa-Barreto (Auteur), Ricardo Neves Marreto (Auteur), Tais Gratieri (Auteur), Guilherme M. Gelfuso (Auteur), Marcilio Cunha-Filho (Auteur)
• Format: Livre
• Publié: MDPI AG, 2020-08-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Here, we assessed the feasibility of hot-melt extrusion (HME) to obtain effervescent drug products for the first time. For this, a combined mixture design was employed using paracetamol as a model drug. Extrudates were obtained under reduced torque (up to 0.3 Nm) at 100 °C to preserve the stability...