Orally Bioavailable Proteolysis-Targeting Chimeras: An Innovative Approach in the Golden Era of Discovering Small-Molecule Cancer Drugs

• Главные авторы: Rohan Kalyan Rej (Автор), Srinivasa Rao Allu (Автор), Joyeeta Roy (Автор), Ranjan Kumar Acharyya (Автор), I. N. Chaithanya Kiran (Автор), Yesu Addepalli (Автор), V. Dhamodharan (Автор)
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• Опубликовано: MDPI AG, 2024-04-01T00:00:00Z.
• Предметы: article
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Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality that show promise to open a target space not accessible to conventional small molecules via a degradation-based mechanism. PROTAC degraders, due to their bifunctional nature, which is categorized as 'beyond the Rule o...