Orally Bioavailable Proteolysis-Targeting Chimeras: An Innovative Approach in the Golden Era of Discovering Small-Molecule Cancer Drugs

• المؤلفون الرئيسيون: Rohan Kalyan Rej (مؤلف), Srinivasa Rao Allu (مؤلف), Joyeeta Roy (مؤلف), Ranjan Kumar Acharyya (مؤلف), I. N. Chaithanya Kiran (مؤلف), Yesu Addepalli (مؤلف), V. Dhamodharan (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2024-04-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Proteolysis-targeting chimeras (PROTACs) are an emerging therapeutic modality that show promise to open a target space not accessible to conventional small molecules via a degradation-based mechanism. PROTAC degraders, due to their bifunctional nature, which is categorized as 'beyond the Rule o...