Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice

• Hauptverfasser: Kazuyoshi Furukawa (Verfasst von), Kahori Okamoto-Matsuda (Verfasst von), Kouji H. Harada (Verfasst von), Mutsuko Minata (Verfasst von), Toshiaki Hitomi (Verfasst von), Hatasu Kobayashi (Verfasst von), Akio Koizumi (Verfasst von)
• Format: Buch
• Veröffentlicht: Komiyama Printing Co. Ltd, 2024-03-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Background: Perfluorooctanoic acid (PFOA) is one of the major per- and polyfluoroalkyl substances. The role of ATP-binding cassette (ABC) transporters in PFOA toxicokinetics is unknown. Methods: In this study, two ABC transporters, ABCB1 and ABCB4, were examined in mice with single intravenous PFOA...