Role of ABCB1 and ABCB4 in renal and biliary excretion of perfluorooctanoic acid in mice

• Main Authors: Kazuyoshi Furukawa (Author), Kahori Okamoto-Matsuda (Author), Kouji H. Harada (Author), Mutsuko Minata (Author), Toshiaki Hitomi (Author), Hatasu Kobayashi (Author), Akio Koizumi (Author)
• Format: Book
• Published: Komiyama Printing Co. Ltd, 2024-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Perfluorooctanoic acid (PFOA) is one of the major per- and polyfluoroalkyl substances. The role of ATP-binding cassette (ABC) transporters in PFOA toxicokinetics is unknown. Methods: In this study, two ABC transporters, ABCB1 and ABCB4, were examined in mice with single intravenous PFOA...