Inhibition of oncogene-induced inflammatory chemokines using a farnesyltransferase inhibitor

• Hlavní autoři: Rothstein Jay L (Autor), Testa James S (Autor), DeGeorge Brent R (Autor), DeGeorge Katharine C (Autor)
• Médium: Kniha
• Vydáno: BMC, 2008-02-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

<p>Abstract</p> <p>Background</p> <p>Farnesyltransferase inhibitors (FTI) are small molecule agents originally formulated to inhibit the oncogenic functions of Ras. Although subsequent analysis of FTI activity revealed wider effects on other pathways, the drug has been...